BETA-BLOCKERS AND RENOPROTECTION: THE POTENTIAL OF CARVEDILOL

Meta-analysis of carvedilol versus beta 1 selective beta-blockers (atenolol, bisoprolol, metoprolol, and nebivolol).

Because carvedilol is a unique vasodilating β blocker (BB) exerting antioxidant activity and pleiotropic effects, it was theorized that it may confer more potent beneficial effects on cardiovascular mortality and morbidity in acute myocardial infarction (AMI) and heart failure (HF) settings. A systematic review and meta-analysis was performed of randomized, controlled, direct-comparison trials ...

Are beta blockers new potential anticancer agents?

β-Blockers have been one of the most widely used and versatile drugs for the past half a century. A new potential for their use as anti-cancer drugs has emerged in the past few years. Various retrospective case control studies have been suggestive that use of β-blockers before the diagnosis of cancer could have preventive and protective effects against non-small cell lung carcinoma, melanoma, a...

A Systematic Review of the Beta-Blockers Carvedilol and Metoprolol for the Treatment of Chronic Heart Failure

Heart failure (HF) is one of the most deadly and costly diseases worldwide. In the United States alone, HF contributes to 1 in every 9 deaths and consumes over $24 billion in healthcare resources. Current estimates project nearly a doubling in the prevalence of HF and almost a tripling in costs between the years 2012 and 2030 [1,2]. While the development of novel therapeutics remains an importa...

Beta-blockers.

Beta-blockers and asthma.

In a single-blind, randomised, crossover study in 10 asthmatic patients, the effects of approximately equipotent oral doses of 3 cardioselective beta-blockers-atenolol (100 mg), metoprolol (100 mg), and acebutolol (300 mg)-and 4 non-cardioselective beta-blockers-proranolol (100 mg), oxprenolol (100 mg), pindolol (5 mg), and timolol (10 mg) upon FEV1 were compared. All drugs, except pindolol, pr...